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Crosslinking Products

Solulink’s proprietary linker technology is an innovative, catalyzed, UV-traceable, heterobifunctional linker technology that offers greater efficiency and yield in a considerably simpler method for linking any two biomolecules together.

  • S-HyNic (succinimidyl-6-hydrazino-nicotinamide) linker is conjugated to biomolecule 1 through primary amines (or thiols with maleimide) on proteins, oligos, peptides, carbohydrates, or surfaces.
  • 4FB (4-formylbenzamide) linker is conjugated to biomolecule 2 through primary amines (or thiols with maleimide) on proteins, oligos, peptides, carbohydrates, or surfaces.
  • HyNic-modified biomolecule 1 is incubated with 4FB-modified biomolecule 2 in a TurboLink™ catalyzed conjugation reaction.

The result is two biomolecules conjugated through a UV-traceable, stable bond (bis-arylhydrazone) with measurable absorbance at 354 nm. Any two proteins, oligos, peptides, etc., regardless of molecular weight, can be efficiently conjugated. Solulink offers a variety of versions of its linkers – maleimido for thiols, esters for amino.

Solulink Advantages

  • Catalyzed Conjugation – The TurboLink catalyst means faster kinetics for greater efficiency and yields
  • Quantifiable – Conjugate bond is UV-traceable for simple and direct quantification
  • Stability – 10 times more stable than any other conjugation linker
  • Specificity – Two-linker method avoids homoconjugate formation
  • Water Soluble – “Sulfo” versions eliminate hazardous organic solvents like DMF
  • Efficient – >80% efficient linker-biomolecule conjugations
  • Robust – The conjugate bond is stable to 92˚C and to pH values ranging from pH 2.0–10.0

Solulink’s proprietary linker technology is available as linker reagents, easy-to-use kits, and bead products in bulk quantities to research and commercial organizations worldwide to enable next-generation biomedical assays and detection systems.

 

Cat. No. Product Name Size Price
S-9010-1 Protein-Protein Conjugation Kit Kit $405.00
S-9011-1 Protein-Oligo Conjugation Kit Kit-2 conjugations $405.00
A-9202-001 Antibody-Oligonucleotide All-in-One Conjugation Kit Kit- conjugates 100ug of antibody $445.00
S-1002-105 S-HyNic Crosslinker (DMF Soluble) 5 x 1.0 mg $160.00
S-1002-010 S-HyNic Crosslinker (DMF Soluble) 10 mg $235.00
S-1011-105 Sulfo S-HyNic Crosslinker (Water Soluble) 5 x 1.0 mg $235.00
S-1011-010 Sulfo S-HyNic Crosslinker (Water Soluble) 10 mg $310.00
S-1004-105 S-4FB Crosslinker (DMF Soluble) 5 x 1.0 mg $105.00
S-1004-010 S-4FB Crosslinker (DMF Soluble) 10 mg $155.00
S-1008-105 Sulfo-S-4FB Crosslinker (Water Soluble) 5 x 1.0 mg $160.00
S-1008-010 Sulfo-S-4FB Crosslinker (Water Soluble) 10 mg $265.00
S-1007-105 C6-S-4FB Crosslinker 5 x 1.0 mg $160.00
S-1037-010 S-SS-4FB Cleavable Crosslinker 10 mg $315.00
HL-1002-025 HyNic Silane 25 mg $365.00
S-1001-010 SHNH Crosslinker (HyNic for Technitium Labeling) 10 mg $265.00
S-1003-010 SHTH Crosslinker (Heat Stable HyNic) Please inquire for pricing $0.00
S-1013-250 A4FB-Phosphoramidite 250 mg $345.00
S-1013-1000 A4FB-Phosphoramidite 1,000 mg $945.00
S-1009-010 MHPH (Maleimide HyNic) Crosslinker 10 mg $265.00